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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well lead to a rise in methadone plasma concentrations, which could cause potentially deadly respiratory despair. In addition, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers might also end in an increase i